The COVID-19 pandemic has led to a significant number of patients experiencing severe acute respiratory syndrome (SARS) and requiring prolonged stays in intensive care units (ICUs). Many of these patients, up to 80%, require invasive mechanical ventilation. Ventilator-associated pneumonia (VAP), a common ICU-acquired infection, poses diagnostic challenges due to its clinical resemblance to non-infectious conditions, such as radiographic infiltrates, systemic inflammation, and impaired oxygenation. The COVID-19 pandemic has persisted for over two years, and ventilator-associated pneumonia (VAP), including cases arising 48 hours post-intubation, remains challenging for intensive care professionals. Early reports noted a high incidence of nosocomial pneumonia, particularly VAP, in critically ill SARS-CoV-2-infected patients.1
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