A 30-year-old woman visited the clinic for an examination of her diabetic retinopathy. She had type 2 diabetes and had moderate non-proliferative diabetic retinopathy with an HbA1c of 12%. No treatment was given, but during the follow-up period, her retinopathy worsened, and pan-retinal photocoagulation was applied to both eyes.
Although mild vitreous haemorrhage developed in both eyes during the pan-retinal photocoagulation, the retinopathy became stable with proliferative tissues surrounding the optic disc in both eyes. Diabetic macular oedema (DME) did not develop during and immediately after the pan-retinal photocoagulation in both eyes.
She had been prescribed pioglitazone for controlling hyperglycemia. Two weeks after taking pioglitazone, she visited our clinic. Her face was edematous, and she had gained weight. Optical coherence tomography (OCT) showed severe DME in both eyes and the right eye; a serous retinal detachment was seen, as shown in the figure. The physician suspected pioglitazone for DME and asked the patient to stop the pioglitazone. Two weeks later, her vision improved to 0.8 OD and 0.5 OS.
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