Dydrogesterone in the tre...

Dydrogesterone in the treatment of habitual abortion In one controlled, randomised but unblinded clinical trial, 114 women (aged 20–34 years) with a history of habitual abortions received either dydrogesterone (10 mg p.o. twice daily), human chorionic gonadotropin (hCG, 5000 IU i.m. once every 4 days) or no treatment until the 12th week of gestation. Treatment was started as soon as possible after confirmation of the pregnancy. Both dydrogesterone and hCG significantly reduced the abortion rate as compared with untreated controls (14% versus 16.5% Conclusion The amount of evidence from published in vitro and in vivo studies in rodents, as well as in vitro and preclinical data in women, yield a promising view of a potent role for dydrogesterone in the management of threatened and recurrent abortion. Whether dydrogesterone repeatedly and reproducibly lowers abortion rates and therefore also confers a practical, and not just a theoretical, advantage to these groups of women needs to be confirmed in reliable trials. As previously mentioned, one such