MQ-Diabetic Peripheral Ne...

The International Diabetes Federation estimates that 425 million people worldwide have type 1 diabetes, making it the largest global epidemic of the 21st century. 73 million people in India and 30 million in the United States have diabetes. These numbers are dwarfed by the number of individuals with prediabetes, which is estimated to be 133 million in India and 85 million in the United States. Diabetic neuropathy is a highly prevalent condition that substantially affects patients by increasing falls, causing pain, and reducing quality of life. It preferentially targets sensory axons, autonomic axons, and later, to a lesser extent, motor axons. Nerves are particularly sensitive to fluctuations in blood glucose levels because neurons have continuously high glucose demands and are vulnerable to episodes of glycolytic and anaerobic metabolism.