Drug-induced gingival overgrowth (DIGO), also known as drug-induced gingival enlargement and formerly termed drug-induced gingival hyperplasia, is a side effect associated with certain medications, where the unintended target organ is the gingival tissue. The primary classes of drugs implicated in this condition include anticonvulsants, immunosuppressants, and calcium channel blockers. Gingival overgrowth compromises proper dental hygiene and leads to painful chewing and eating, in addition to its cosmetic impact. The initial approach to treatment typically involves non-surgical methods, emphasizing adequate plaque control and discontinuation or alteration of the causative drug. In recent times, azithromycin has garnered significant attention for its efficacy in addressing gingival overgrowth in individuals taking cyclosporin A, obviating the necessity to switch to an alternative medication. Surgical intervention is considered only when non-surgical treatments prove ineffective. Nevertheless, recurrences are frequent, and the outcomes typically endure for around twelve months.
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