MQ- Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder driven by a dominant mutation in the HTT gene, yet lacks effective treatments. Metallomic imbalances have been observed in the HD brain, including altered levels of copper, manganese, sodium, zinc, selenium, and iron. These disruptions may contribute to HD's pathogenesis since these metals play crucial roles in antioxidative processes and maintaining cellular energy production. Identifying these mechanisms and potential therapeutic targets is vital due to the absence of disease-slowing or curative treatments for HD.