Risk of epithelial ovaria...

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by disruptions in ovulation, elevated androgenic hormone levels, the presence of polycystic ovaries, and metabolic irregularities. The potential link between PCOS and epithelial ovarian tumors is biologically plausible, as factors inherent to PCOS may contribute to tumor development. For instance, established risk factors for hormone-sensitive tumors, such as elevated androgenic hormones, impaired reproductive function, and obesity, are prevalent in individuals with PCOS. Conversely, the reduced risk of these tumors may be associated with anovulation, a common feature of PCOS. Additionally, the presence of androgen receptors in normal ovarian cells and certain ovarian tumors, along with genetic and epigenetic factors, may play a role in influencing the relationship between PCOS and ovarian tumors.