Donanemab for Alzheimer's...

The initial occurrence of β-amyloid deposition in the brain marks the early stages of Alzheimer's disease. This process triggers the formation of neurofibrillary tangles, which consist of tau protein, along with other distinct brain alterations known as the amyloid cascade. The presence of abnormal β-amyloid is a crucial characteristic of Alzheimer's disease, as defined by the 2018 National Institute on Aging and the Alzheimer's Association Research Framework. Consequently, it remains a primary focus in Alzheimer's disease research and the development of potential treatments.