Oral squamous cell carcinoma (OSCC) is the most common cancer in the oral cavity. However, the relationship between the genetic susceptibility of circCHST15 and OSCC remains unclear. Genetic variants of circCHST15 were screened using a genotyping analysis from 1044 patients with OSCC and 3199 healthy participants. The circCHST15 expression was detected in 32 pairs of OSCC tissues. In addition, the circular RNA quantitative trait locus analysis and the reporter gene assay were performed for verification. This genetic variation could possibly elevate the circCHST15 expression level by altering the structure of circular RNAs and affecting transcription factor binding. The results of this study suggested that genetic variants of circCHST15 may contribute to OSCC susceptibility.

Genetic Variants of circCHST15 and Oral Squamous Cell Carcinoma: Insights from a Genotyping Analysis

NEUROLOGY

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ENDO-DIABETOLOGY

CALERIE analysis identifies muscle genes and pathways associated with preserving strength during caloric restriction-induced weight loss.

Muscle Genes Linked to Strength Preservation During Weight Loss

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GYNAECOLOGY - IVF

Study finds cerebral blood-flow differences mainly distinguish sFGR types, while myocardial changes remain a research phenotype.

Cerebral and Myocardial Changes in Twin sFGR | Study

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UK Biobank study finds EOSS and DMO classify obesity severity differently, particularly in early or subclinical disease.

EOSS vs DMO: Comparing Obesity Classification Frameworks

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UROLOGY

Study finds ED in 93.8% of men with atherosclerotic disease, supporting its role as a marker of systemic vascular pathology.

Erectile Dysfunction Prevalence in Patients With Atherosclerosis

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OPHTHALMOLOGY

Meta-analysis finds reproxalap improves tear production in DED, but frequent transient instillation-site irritation warrants consideration.

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PULMONOLOGY

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DENTISTRY

Review explores S. mutans membrane vesicles and their potential roles in caries, oral microbial signaling and systemic disease.

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AI analysis found physical inactivity was the strongest county-level predictor of obesity, with the model explaining 78% of variance.

Physical Inactivity Linked to County-Level Obesity Prevalence

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Global data reveal distinct obesity trends in early and later adulthood across 196 countries from 1990 to 2022.

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Omics research reveals how circadian disruption from night shifts may increase obesity risk and alter metabolic health.

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Review identifies barriers to cervical screening after sexual trauma and highlights trauma-informed approaches to improve care.

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Major weight loss or gain was associated with higher dementia risk in younger adults with diabetes and depression.

Weight Change and Dementia Risk in Young Adults With T2DM

A nationwide Korean cohort of 17,851 adults aged 20–59 with type 2 diabetes and depression found that both substantial weight loss and weight gain were associated with higher subsequent dementia risk over 10.3 years. The findings suggest weight trajectories may serve as observable risk markers, although associations with extreme weight changes require cautious interpretation.

Machine learning revealed population-specific CVD risk patterns among CKD patients in China and the United States.

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CRITICAL CARE

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MI-E for Airway Clearance in Critically Ill Children

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Association of genetic va...

Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population