Change in Left Ventricular Ejection Fraction With Coronary Artery Revascularization and Subsequent Risk for Adverse Cardiovascular Outcomes

Coronary revascularization is recommended to treat ischemic cardiomyopathy. However, revascularization-associated ejection fraction (EF) change to subsequent outcomes has not been elucidated. Over follow-up (mean/maximum 5/14 years) 56% died. Each 5% improvement in delta-EF was associated with statistically significant reductions in death and heart failure hospitalization days of 5% (95% CI, 3%–7%) and 10% (95% CI, 5%–15%), respectively, in the total sample and 6% (95% CI, 4%–8%) and 10% (95% CI, 5%–16%), respectively, in the PCI subgroup. Revascularization-associated EF improvement was associated with significant reductions in mortality and heart failure hospitalization burden, particularly in the PCI subgroup.