Clinical parameters associated with altered sperm DNA fragmentation index among primary infertile men – findings from a real‐life cross‐sectional study

Recurrent pregnancy loss (RPL) and unexplained infertility are the current indications to test sperm DNA fragmentation (SDF) according to the EAU Guidelines on sexual and reproductive health. To identify a novel and better-performing model to diagnose primary infertile men presenting with altered SDF and to outlie its predictive ability concerning current EAU Guidelines’ recommendations. Applying the EAU sexual and reproductive health guidelines does not ensure proper identification of primary infertile men with pathological SDF. The study proposes a novel and better-performing predictive model to identify those infertile men with altered SDF at first clinical assessment. As altered SDF has been widely linked with the inability to conceive, this second‐level test could be further implemented over the diagnostic work‐up of a broader subset of patients presenting for MFI. Therefore, the study proposes a better-performing model to identify this specific category of patients.