Fetal cardiac hemodynamics and neonatal cerebral hemodynamics and oxygen metabolism in transposition of the great arteries

Hemodynamic abnormalities and brain development disorders were previously reported in fetuses and children with transposition of the great arteries (TGA) and intact ventricular septum (TGA&IVS). A ventricular septal defect (VSD) is considered an additional risk factor for brain development, but literature describing this population is sparse. This study's findings indicated that fetal cardiac and neonatal cerebral hemodynamic/metabolic alterations were observed in both TGA groups compared to controls. A higher level of preoperative hypoxemia was observed in TGA&VSD. Post‐surgical cerebral adaptive mechanisms are likely different between TGA groups.