Impact of Maternal Vitamin D Changes During Pregnancy on Maternal Adverse Events: Insights from a Case-Control Study

Maternal vitamin D deficiency in pregnancy is linked to adverse maternal events (MAE), but the impact of supplementation remains uncertain. This study analyzed 403 cases with MAE and 403 controls from a vitamin D deficiency screening program. Results showed higher MAE in women remaining deficient or worsening, with a moderate-to-high predictive performance using a random forest model (AUC: 0.74, sensitivity: 72.6%, specificity: 69%). Systolic blood pressure was the most influential variable. Addressing vitamin D deficiency during pregnancy could mitigate MAE risks.