Maternal intake of folate and folic acid during pregnancy and pubertal timing in girls and boys

The study investigates the association between maternal folate intake during pregnancy and pubertal timing in boys and girls. The research analyzed 6585 girls and 6326 boys from a Danish population-based Puberty Cohort and used multivariable interval-censored regression models to estimate mean monthly differences according to exposure groups. The study found that prenatal exposure to low maternal intake of total folate in mid-pregnancy was not associated with pubertal timing in girls but was associated with slightly later pubertal timing in boys, which is not of clinical importance.