Pathogenic Variants Associated With Dilated Cardiomyopathy Predict Outcome in Pediatric Myocarditis

Myocarditis is one of the most common causes leading to heart failure in children and a possible genetic background has been postulated. We sought to characterize the clinical and genetic characteristics in patients with myocarditis ≤18 years of age to predict outcome. Genetics in Pediatric Myocarditis patients were divided into subgroups according to the phenotype of dilated cardiomyopathy at presentation, resulting in 22 patients without DCM (myocarditis without phenotype of DCM) and 20 patients with DCM (myocarditis with phenotype of DCM). Myocarditis with phenotype of DCM patients were younger than myocarditis without phenotype of DCM patients (median age 16). At least one likely pathogenic/pathogenic variant was identified in 9 out of 42 patients , 8 of them were heterozygous, and 7 out of 9 were in myocarditis with phenotype of DCM...