Patients with psoriasis have a dysbiotic taxonomic and functional gut microbiota

Accumulating evidence supports the findings of altered gut microbiota in patients with the autoimmune disease; however, existing literature on the role of the gut microbiota in patients with psoriasis have demonstrated conflicting results and have mainly been based on 16s rRNA gene sequencing analysis. To examine whether the gut microbiota of patients with psoriasis was altered in composition and functional potentials compared with healthy controls and as a second approach compared with healthy cohabitant partners; further, to investigate relationships to disease severity and seasonal impact on the gut microbiota. The findings of different gut microbiota in composition and functional potentials between patients with psoriasis and healthy controls support a linkage between the gut microbiota and psoriasis. However, these findings need to be validated in more extensive studies, and a potential causal relationship between gut microbiota and psoriasis still needs to be shown.