The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) are distinct clinical entities. Yet, there is scant evidence for associations of proteomic signatures with the future development of HFpEF versus HFrEF.They identified five protein biomarkers of new-onset HFpEF representing pathways of inflammation, cardiac stress, and vascular stiffness, which partly overlapped with HFrEF. The authors found 14 biomarkers associated with new-onset HFrEF, with some distinct associations, including myeloperoxidase, resistin, and paraoxonase-1. These findings provide insights into similarities and differences in the development of HF subtypes.