A Problem for Generations: Impact of E-Cigarette Type on Immune Homeostasis

The highlighted differences between third- and fourth-generation e-cigarettes in their study suggest that prior published data generated from first- through third-generation e-devices may not apply to the most current e-cigarette users, who primarily use fourth-generation devices. Specifically, the immunologic and pathologic consequences of e-cigarette use differ depending on the e-device and e-liquid. Finally, in this era of multiinhalant use, when many e-cigarette vapers also smoke conventional tobacco (dual use) and/or use marijuana (smoke or vape), it must undertake studies to understand how these inhalants may interact to cause new or more severe effects on human health.