ENDO-DIABETOLOGY

This study aimed to explore the following: 1) the impact of Champ4Life’s intervention on intuitive eating and food reward; and 2) associations between changes in eating behaviour and body composition. A total of 94 former athletes (mean [SD], BMI = 31.1 [4.3] kg/m2, age = 43.0 [9.4] years, 34% female) assigned to intervention (n = 49) and control groups (n = 45) underwent 4 months of active weight loss (WL) followed by 8 months of WL maintenance. The WL was −4.8% (4.9%) and 0.3% (2.6%) for the intervention and control groups, respectively. Food reward decreased after a moderate WL intervention. Participants successfully maintained their reduced weight, and most of the changes in eating behaviour remained significant at the end of the follow-up period. Lifestyle interventions aiming at WL should also consider intuitive eating and food rewards.

Exploring the Impact of Champ4Life Intervention on Intuitive Eating and Food Reward: A Study on Former Athletes' Eating Behavior and Body Composition Changes

GENERAL MEDICINE

PULMONOLOGY

Systems vaccinology found comparable antibody responses but attenuated proteomic and transcriptomic immune remodeling after COVID-19 vaccination in treated pulmonary tuberculosis patients.

COVID-19 Vaccination Shows Attenuated Immune Remodeling in Pulmonary TB

A nested analysis of a multicenter phase IV randomized controlled trial compared 38 pulmonary tuberculosis (PTB) patients receiving anti-tuberculosis therapy with 38 healthy controls following two doses of an inactivated COVID-19 vaccine. Although both groups developed comparable neutralizing antibody titers and seroconversion rates, PTB patients showed distinct baseline immune abnormalities, including reduced proteins involved in vesicle transport and phagocytosis and pro-inflammatory transcriptional changes. After vaccination, healthy controls demonstrated broad proteomic and transcriptomic remodeling, whereas PTB patients showed limited molecular and inferred immune-cell changes, suggesting attenuated systems-level immune activation despite preserved short-term antibody responses.

DERMATOLOGY

Emerging biologics and targeted small molecules are expanding treatment options for hidradenitis suppurativa, despite variable trial results.

Emerging Targeted Therapies for Hidradenitis Suppurativa

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A Danish cohort found GLP-1RA use was more frequent and earlier in hidradenitis suppurativa, with reduced treatment and surgical utilization after initiation.

GLP-1RA Use and Treatment Patterns in Hidradenitis Suppurativa

A nationwide Danish register-based cohort study compared 12,581 patients with hidradenitis suppurativa (HS) with 9,824 psoriasis patients and 12,581 matched background controls. During follow-up, 8.2% of HS patients initiated GLP-1 receptor agonists (GLP-1RAs), compared with 5.7% of psoriasis patients and 3.2% of controls. GLP-1RA initiation occurred earlier in HS patients, at a mean of 8.88 years, versus 10.1 and 10.2 years in the psoriasis and control groups, respectively. After initiation, lower rates of surgical procedures and systemic medication use were observed, although similar declines occurred among matched non-users, limiting conclusions about a treatment effect.

GYNAECOLOGY - IVF

A 20-case study found ventriculomegaly was the most common prenatal finding in fetuses with DLL1 variants or 6q27 deletions, supporting further genetic evaluation.

Prenatal Ultrasound Features of DLL1 Variants and 6q27 Deletions

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RHEUMATOLOGY

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Plasma Calprotectin Linked to Disease Activity and Autoantibody Burden in RA

A cross-sectional study of 4,521 Scandinavian patients with rheumatoid arthritis (RA) evaluated plasma calprotectin in relation to inflammatory markers, clinical disease activity, and autoantibody profiles. Calprotectin correlated with ESR (ρ=0.53), CRP (ρ=0.47), VAS pain (ρ=0.24), SJC28 (ρ=0.39), and TJC28 (ρ=0.26). Patients with both elevated CRP and calprotectin had greater pain and joint counts than those with elevated CRP alone. Elevated calprotectin was also associated with higher positivity and broader responses to anti-modified protein autoantibodies (AMPAs), including anti-CCP2, independent of CRP levels and other clinical factors.

PEDIATRICS

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Maternal Age and Clinical Associations of GBS Colonization in Pregnancy

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OPHTHALMOLOGY

Review highlights imaging, immune testing and molecular diagnostics for probability-based diagnosis and monitoring of tubercular uveitis.

Tubercular Uveitis: Multimodal Imaging and Diagnostic Advances

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Study links socioeconomic and clinical factors to increased odds of complex cataract surgery, supporting improved preoperative risk assessment.

Socioeconomic Factors and Complex Cataract Surgery Risk

A multicentre U.S. study found that socioeconomic factors remained associated with complex cataract surgery even after adjusting for clinical risk factors. Older age, male sex, poorer vision, greater cataract density, Black or Asian race, diabetes, pseudoexfoliation and certain medications were also linked to increased risk, supporting enhanced preoperative risk assessment.

ONCOLOGY

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KDM4A Promotes Metastasis in Testicular Germ Cell Tumors

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Study finds obesity awareness was not associated with BMI or anthropometric measures but varied with family and occupational factors.

Obesity Awareness Not Linked to BMI in Cross-Sectional Study

A cross-sectional study of 123 adults found no significant association between obesity awareness and objective measures such as BMI, waist-hip ratio, or waist-to-height ratio. However, having a family member with obesity and occupational status were associated with awareness levels, highlighting the potential influence of social and behavioral factors.

CARDIOLOGY

Study highlights infrastructure needed to safely scale mainstream cardiac genetic testing in cardiomyopathy patients.

Cardiac Genetic Testing Needs Infrastructure for Safe Scale-Up

A cardiomyopathy program study of 482 patients found pathogenic or likely pathogenic variants in 19.7%, with 18.9% of genotype-positive patients carrying high-risk variants. Variant reclassification affected 1 in 60 patients, while carrier findings accounted for 21.5% of pathogenic variants, highlighting the need for surveillance, genetics referral, and family-screening pathways.

Brazilian study expands FLNC genotype-phenotype data and identifies potential markers for cardiomyopathy risk stratification.

FLNC Variants Linked to Diverse Cardiomyopathy Phenotypes

A Brazilian study of 97 carriers of pathogenic or likely pathogenic FLNC variants found distinct genotype-phenotype patterns across cardiomyopathies. Truncating variants predominated in arrhythmogenic and dilated cardiomyopathy, while missense variants were more common in hypertrophic and restrictive forms. Ventricular arrhythmias, low QRS voltage, and myocardial fibrosis may aid future risk stratification.

NEUROLOGY

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MCA Doppler PI Predicts Fetal Distress During Labor Induction

A prospective study of 529 women undergoing labor induction found that umbilical artery and middle cerebral artery Doppler indices differed significantly between women with and without fetal distress. An MCA PI cutoff of 1.44 predicted fetal distress with 88.9% sensitivity and 80% specificity, supporting Doppler assessment as a potential tool for intrapartum risk evaluation.

Review explores lncRNAs as regulators, biomarkers, and potential therapeutic targets in congenital heart disease.

lncRNAs Show Promise in Congenital Heart Disease Diagnosis

An in-depth review highlights how long noncoding RNAs regulate cardiac development and congenital heart disease through Notch, Wnt/β-catenin, BMP, and TGF-β pathways. Molecules including Braveheart, Fendrr, CARMEN, H19, and MALAT1 may influence cardiac morphogenesis, while circulating and exosomal lncRNAs show promise as prenatal biomarkers.

Study finds antibiotic prophylaxis may not reduce infections after septoplasty, while nasal mupirocin shows promise.

Antibiotic Prophylaxis and Infection Risk After Septoplasty

A retrospective study of 1,169 adult septoplasties found postoperative infections in 1.9% of patients, with no significant difference between those who received preoperative antibiotic prophylaxis and those who did not. Longer surgery and silicone splints increased infection risk, while preoperative nasal mupirocin was associated with no infections and may warrant further study.

Changes in food reward an...

Changes in food reward and intuitive eating after weight loss and maintenance in former athletes with overweight or obesity