Clinical applications of microperimetry in RPGR‐related retinitis pigmentosa: a review

Microperimetry, or fundus‐tracked perimetry, is a precise static‐automated perimetric technique to assess central retinal function. As visual acuity only deteriorates at a late disease stage in RPGR‐related retinitis pigmentosa (RP), alternative markers for disease progression are of great utility. Microperimetry assessment has been of critical value as an outcome measure in a recently reported phase I/II gene therapy trial for RPGR‐related RP, both in terms of detecting safety and efficacy signals. Here, we performed a review of the literature. We describe the principles of microperimetry before outlining specific parameters that may be useful as outcome measures in clinical trial settings. The current state of structure - function correlations between short‐wavelength autofluorescence, optical coherence tomography and adaptive optics in RPGR‐related retinitis pigmentosa are also summarized.