Efficacy and safety of basal‐first titration order in individuals with type 2 diabetes receiving short‐term intensive insulin therapy: An exploratory analysis of BEYOND V

To present the results of an exploratory analysis of the BEYOND V study, in which Chinese individuals with uncontrolled type 2 diabetes (T2D) received short-term intensive insulin therapy (SIIT) during the study run-in using a basal-first insulin titration method. Three hundred ninety-seven entered the run‐in. At the end of SIIT, 374/396 participants (94.4%) had both FBG <7.0 mmol/L and 2‐hour PBG <10 mmol/L, and 282/396had both FBG <6.1 mmol/L and 2‐hour PBG <10 mmol/L. The mean first time was taken to achieve FBG <7 mmol/L, and 2‐hour PBG <10 mmol/L; both were 4.35, 3.88, and 5.04 days, respectively. Hypoglycemia occurred in 99 participants (24.9%). There was no severe hypoglycemia. Titrating basal insulin first is an effective and safe method of SIIT in individuals with T2D, rapidly achieving target glucose levels with a relatively low rate of hypoglycemia.