Caudal pneumatization of the pterygoid process may impact endonasal exposure of the lateral recess of the sphenoid sinus (LRSS). This study aims to explore the implications of a pneumatized pterygoid process for an endonasal transpterygoid approach to the LRSS and to define strategies for preserving or sacrificing the vidian nerve. Pneumatization of the LRSS toward a caudal or superolateral direction may develop independently. Caudal pneumatization of the pterygoid process varies the endonasal exposure of the LRSS.

Caudal Pneumatization of Pterygoid Process and Endonasal Exposure of the Sphenoid Sinus: Implications for Transpterygoid Approach and Vidian Nerve Preservation

GENERAL MEDICINE

PULMONOLOGY

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COVID-19 Vaccination Shows Attenuated Immune Remodeling in Pulmonary TB

A nested analysis of a multicenter phase IV randomized controlled trial compared 38 pulmonary tuberculosis (PTB) patients receiving anti-tuberculosis therapy with 38 healthy controls following two doses of an inactivated COVID-19 vaccine. Although both groups developed comparable neutralizing antibody titers and seroconversion rates, PTB patients showed distinct baseline immune abnormalities, including reduced proteins involved in vesicle transport and phagocytosis and pro-inflammatory transcriptional changes. After vaccination, healthy controls demonstrated broad proteomic and transcriptomic remodeling, whereas PTB patients showed limited molecular and inferred immune-cell changes, suggesting attenuated systems-level immune activation despite preserved short-term antibody responses.

DERMATOLOGY

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Emerging Targeted Therapies for Hidradenitis Suppurativa

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ENDO-DIABETOLOGY

A Danish cohort found GLP-1RA use was more frequent and earlier in hidradenitis suppurativa, with reduced treatment and surgical utilization after initiation.

GLP-1RA Use and Treatment Patterns in Hidradenitis Suppurativa

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GYNAECOLOGY - IVF

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RHEUMATOLOGY

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Plasma Calprotectin Linked to Disease Activity and Autoantibody Burden in RA

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PEDIATRICS

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OPHTHALMOLOGY

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Study links socioeconomic and clinical factors to increased odds of complex cataract surgery, supporting improved preoperative risk assessment.

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ONCOLOGY

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Obesity Awareness Not Linked to BMI in Cross-Sectional Study

A cross-sectional study of 123 adults found no significant association between obesity awareness and objective measures such as BMI, waist-hip ratio, or waist-to-height ratio. However, having a family member with obesity and occupational status were associated with awareness levels, highlighting the potential influence of social and behavioral factors.

CARDIOLOGY

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Cardiac Genetic Testing Needs Infrastructure for Safe Scale-Up

A cardiomyopathy program study of 482 patients found pathogenic or likely pathogenic variants in 19.7%, with 18.9% of genotype-positive patients carrying high-risk variants. Variant reclassification affected 1 in 60 patients, while carrier findings accounted for 21.5% of pathogenic variants, highlighting the need for surveillance, genetics referral, and family-screening pathways.

Brazilian study expands FLNC genotype-phenotype data and identifies potential markers for cardiomyopathy risk stratification.

FLNC Variants Linked to Diverse Cardiomyopathy Phenotypes

A Brazilian study of 97 carriers of pathogenic or likely pathogenic FLNC variants found distinct genotype-phenotype patterns across cardiomyopathies. Truncating variants predominated in arrhythmogenic and dilated cardiomyopathy, while missense variants were more common in hypertrophic and restrictive forms. Ventricular arrhythmias, low QRS voltage, and myocardial fibrosis may aid future risk stratification.

NEUROLOGY

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MCA Doppler PI Predicts Fetal Distress During Labor Induction

A prospective study of 529 women undergoing labor induction found that umbilical artery and middle cerebral artery Doppler indices differed significantly between women with and without fetal distress. An MCA PI cutoff of 1.44 predicted fetal distress with 88.9% sensitivity and 80% specificity, supporting Doppler assessment as a potential tool for intrapartum risk evaluation.

Review explores lncRNAs as regulators, biomarkers, and potential therapeutic targets in congenital heart disease.

lncRNAs Show Promise in Congenital Heart Disease Diagnosis

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Antibiotic Prophylaxis and Infection Risk After Septoplasty

A retrospective study of 1,169 adult septoplasties found postoperative infections in 1.9% of patients, with no significant difference between those who received preoperative antibiotic prophylaxis and those who did not. Longer surgery and silicone splints increased infection risk, while preoperative nasal mupirocin was associated with no infections and may warrant further study.

Endonasal Exposure of Lat...

Endonasal Exposure of Lateral Recess of the Sphenoid Sinus: Significance of Pterygoid Process Pneumatization