The aim of this study was to determine the feasibility of diffusion basis spectrum imaging in multiple sclerosis at 7 T and to investigate the pathological substrates of tissue damage in lesions and normal-appearing white matter. To this end, 43 patients with multiple sclerosis (24 relapsing-remitting, 19 progressive), and 21 healthy control subjects were enrolled. White matter lesions were classified in T1-isointense, T1-hypointense and black holes...

Non-invasive quantification of inflammation, axonal and myelin injury in multiple sclerosis

Dive into the insights from the "Perception Survey on Online Medical Education for Indian Healthcare Practitioners" by MediSage.

Exploring the Landscape of Online Medical Education: A Perception Survey among Indian Healthcare Practitioners

A recent survey conducted by MediSage delves into the perceptions of Indian Healthcare Practitioners (HCPs) regarding online medical education. With 205 participants, the survey explores participation rates, preferred formats, and obstacles faced by HCPs in accessing online medical education. Key findings include 73.41% active participation, with webinars being the preferred choice. Over 50% express confidence in online education, while many advocate for policy changes to address barriers. Mr Bhagwat Dhingra, MD & Founder of MediSage, expresses delight at the positive trend in online healthcare education adoption among HCPs.

Karuna Therapeutics celebrates FDA acceptance of New Drug Application (NDA) for KarXT, a promising treatment for schizophrenia in adults.

Karuna Therapeutics' KarXT NDA Accepted by FDA for Schizophrenia Treatment | PDUFA Date Set for September 26, 2024

Karuna Therapeutics announced the acceptance of its New Drug Application (NDA) for KarXT (xanomeline-trospium) by the U.S. Food and Drug Administration (FDA). The application, targeting schizophrenia treatment in adults, is set for a Prescription Drug User Fee Act (PDUFA) date of September 26, 2024. Positive trial results show improved symptoms without common antipsychotic side effects. KarXT addresses a crucial need for innovative treatments for severe mental illnesses like schizophrenia.

Explore the latest breakthrough as eFFECTOR Therapeutics gains FDA Fast Track designation for Zotatifin in combination with fulvestrant and abemaciclib (ZFA triplet)

eFFECTOR's Zotatifin Receives FDA Fast Track Designation for ER+/HER2- Advanced Breast Cancer Therapy

eFFECTOR Therapeutics has received Fast Track designation from the U.S. FDA for zotatifin, in combination with fulvestrant and abemaciclib (ZFA triplet), as second- or third-line therapy for estrogen receptor-positive (ER+)/human epidermal growth factor-negative (HER2-) advanced or metastatic breast cancer. The designation is granted based on preclinical and clinical data and expedites the review process for drugs addressing severe or life-threatening conditions. eFFECTOR is optimistic about the potential of zotatifin and plans to provide further updates at the 2023 San Antonio Breast Cancer Symposium. Ongoing Phase 1/2 studies assess zotatifin's efficacy in ER+/HER2- breast cancer.

Discover the latest World Health Organization report highlighting a dangerous spike of 5 million malaria cases in 2022, surpassing containment goals.

WHO Report: Alarming Surge in Malaria Cases in 2022 Threatens Global Targets

The World Health Organization (WHO) reports a rise in global malaria cases, reaching 249 million in 2022, surpassing pre-pandemic levels by 16 million. Challenges include COVID-19 disruptions, drug resistance, and climate change impacts. The 2023 World Malaria Report explores climate-malaria connections, emphasizing climate's role in mosquito behaviour and disease transmission. Climate change poses a substantial risk, necessitating resilient malaria responses. Despite hurdles, progress includes the rollout of WHO-recommended vaccines and strides toward malaria elimination in low-burden countries. Urgent action, increased resources, and innovative strategies are advocated for effective malaria control amidst evolving challenges.

Stay informed about the U.S. FDA's investigation into quality issues with plastic syringes manufactured in China, including leaks and breakages.

FDA Investigation: Quality Concerns with Chinese-Made Plastic Syringes Sparks Potential Market Restrictions

The U.S. Food and Drug Administration (FDA) is investigating quality issues associated with plastic syringes manufactured in China, including leaks and breakages. Based on its findings, the FDA may collaborate with federal partners to restrict the entry of Chinese-made plastic syringes into the U.S. market. Changes in syringe dimensions during production have prompted recent recalls and complaints. The FDA recommends that patients and health providers consider alternatives outside of China during the investigation, as potential device failures could impact accurate medication dosing. The agency pledges to work with manufacturers to implement necessary corrective actions.

Explore the impact of conservative airway management, specifically intubation withholding, versus routine intubation practice on clinical outcomes for comatose patients with acute poisoning and a Glasgow Coma Scale score less than 9.

Intubation Withholding vs Routine Practice in Acute Poisoning: Clinical Outcomes in Comatose Patients

A recent multicenter trial in France explored the impact of withholding tracheal intubation in comatose patients with acute poisoning and a Glasgow Coma Scale score below 9. The study conducted in 20 emergency departments and one intensive care unit revealed that a conservative approach, withholding intubation, demonstrated significant clinical benefits. The intervention group experienced lower rates of adverse events and pneumonia than the control group. The findings suggest that, in comatose patients with suspected acute poisoning, a strategy of withholding intubation yields better outcomes in terms of in-hospital death, ICU stay, and hospital stay.

Explore the findings of a multicenter trial investigating the efficacy of inhaled amikacin in reducing ventilator-associated pneumonia among critically ill adults undergoing invasive mechanical ventilation.

Inhaled Amikacin for Ventilator-Associated Pneumonia Prevention: Results from a Double-Blind, Randomized Trial

In a recent multicenter trial involving 850 critically ill adults on invasive mechanical ventilation for over 72 hours, the study investigated the impact of inhaled amikacin (20 mg/kg of ideal body weight) versus placebo over three days. Results revealed a significant reduction in ventilator-associated pneumonia occurrence after 28 days in the amikacin group (15%) compared to the placebo group (22%). Additionally, infection-related ventilator-associated complications were lower with amikacin. The study demonstrated the efficacy of a 3-day course of inhaled amikacin in lessening ventilator-associated pneumonia burden.

Discover the findings of a multicenter observational study in Spain, investigating the risk factors associated with heart failure worsening in patients with atrial fibrillation and chronic heart failure taking rivaroxaban for over 4 months.

Exploring Risk Factors for Heart Failure Worsening in Atrial Fibrillation Patients on Rivaroxaban: A Prospective Study in Spain

A multicenter study conducted in Spain involving 672 patients explored risk factors for heart failure (HF) worsening in individuals with atrial fibrillation (AF) and HF taking rivaroxaban for over four months. After 24 months, 24.9% experienced HF worsening, 11.6% died, and 2.9% had thromboembolic events. Factors like older age, chronic obstructive pulmonary disease history, prior use of vitamin K antagonists, and certain cardiomyopathies were linked to HF worsening. Only 6.9% permanently discontinued rivaroxaban. Understanding these risk factors is crucial for comprehensive management of the patient population.

Explore the impact of heart failure hospitalization on mortality, morbidity, and healthcare resource use in adults with congenital heart disease (ACHD).

Outcomes of Heart Failure Hospitalization in Adults with Congenital Heart Disease: A Comprehensive Analysis

The study investigates outcomes post heart failure (HF) hospitalization in US adults with congenital heart disease (CHD). Analyzing de-identified administrative claims data from 26,454 unique adult congenital heart disease (ACHD) admissions (2010–2020), 22% were ACHDHF+ and 78% ACHDHF−. ACHDHF+ hospitalizations rose from 6.6% to 14.0%. Over a mean 2.23-year follow-up, ACHDHF+ patients faced higher mortality, major adverse events, and increased health resource use, but recent cardiology clinic visits correlated with reduced risks. The study emphasizes the impact of HF hospitalization on ACHD outcomes and highlights potential mitigating factors.

Discover the results of a comprehensive Mendelian randomization study investigating the potential causal relationship between Rheumatoid Arthritis (RA) and hypothyroidism/hyperthyroidism.

Exploring the Causal Link Between Rheumatoid Arthritis and Thyroid Dysfunction: A Mendelian Randomization Study

The study utilized Mendelian randomization (MR) techniques to explore the controversial link between Rheumatoid arthritis (RA) and hypothyroidism/hyperthyroidism. Univariate analysis reveals RA's causative influence on hypothyroidism and hyperthyroidism. When considering hypothyroidism/hyperthyroidism as exposure variables, a causal link is observed only with hypothyroidism. Multivariate MR analyses, adjusting for factors like BMI and smoking, support the causal association between RA and hypothyroidism/hyperthyroidism, confirming hypothyroidism's impact on RA but finding no evidence for hyperthyroidism affecting RA risk. The study sheds light on these complex relationships through robust analytical methods.

Uncover the intricate interplay between thyroid dysfunction and cutaneous malignant melanoma (CMM) through a comprehensive two-sample Mendelian randomization study.

Exploring the Bidirectional Relationship Between Thyroid Dysfunction and Cutaneous Malignant Melanoma: A Two-Sample Mendelian Randomization Study

A bidirectional two-sample Mendelian randomization study analyzing 9,851,867 SNPs in a European population explored the link between thyroid dysfunction and cutaneous malignant melanoma (CMM). Genetically predicted hypothyroidism negatively correlated with CMM probability (OR=0.987, 95%CI=0.075-0.999, p=0.041), suggesting hypothyroidism might be a protective factor. Hyperthyroidism showed no significant impact on CMM risk. The findings hint at a potential weak causal association, emphasizing the need for in-depth investigations into the underlying mechanisms.

Explore the findings of a 4-month high-protein, energy-restricted dietary weight management study involving 130 overweight or obese individuals without metabolic syndrome.

Osteocalcin's Protective Role in Muscle Loss During Weight Reduction in Individuals without Metabolic Syndrome

The study involving 130 overweight or obese individuals without metabolic syndrome explored the protective role of osteocalcin (OC) against muscle loss during a 4-month high-protein, energy-restricted weight management program. Results showed a decrease in various metabolic indicators post-weight loss, including BMI, body fat percentage, and insulin levels. Notably, OC demonstrated a positive correlation with skeletal muscle percentage. The findings suggest that OC significantly protects muscle mass during weight reduction, particularly in males on high-protein diets without metabolic syndrome.

Explore a comprehensive study on proximal biliary plastic stent migration (PSM) with insights into rates, successful retrieval outcomes, and key risk factors.

Study on Proximal Biliary Plastic Stent Migration: Rates, Retrieval Outcomes, and Risk Factors

A recent study analyzed an endoscopy database from January 2016 to January 2021 involving 1137 patients who underwent stent removal or repeat endoscopic retrograde cholangiopancreatography (ERCP). The study aimed to determine the rate of proximal biliary plastic stent migration (PSM), retrieval outcomes, and associated factors. Results indicated a 6.5% PSM rate, with successful retrieval in 94.59% of cases. Factors such as stent size, duration of indwelling stent, sphincteroplasty, and bile duct dilation were linked to increased PSM risk. Propensity score matching highlighted 7-Fr stent size and prolonged stent indwelling as significant contributors to proximal migration.

Explore the findings of a comprehensive cross-sectional study utilizing cone-beam computed tomography (CBCT) to analyze 244 scans.

Cross-Sectional CBCT Study: Assessing Accessory Maxillary Ostium Frequency and Its Correlation with Sinusitis and Anatomical Variations

A cross-sectional study using cone-beam computed tomography (CBCT) examined 244 scans to assess accessory maxillary ostium (AMO) frequency in patients with/without sinusitis and its correlation with anatomical variations. The study found no significant correlation between AMO and maxillary sinusitis. While AMO frequency showed no correlation with anatomical variations, gender significantly influenced AMO presence. The study revealed higher AMO frequency in females in the normal group and males with sinusitis. Significant differences were observed in the frequency of paradoxical concha, bifid concha, and primary maxillary ostium obstruction between the two groups.

Explore the nuanced differences in factors influencing medical lethality among 253 elderly suicide attempters and 351 middle-aged individuals in the emergency room.

Sex-Specific Factors in Elderly Suicide Attempts: A Comprehensive Analysis of 253 Cases

The study analyzed 253 elderly suicide attempters and 351 middle-aged individuals in the emergency room to identify sex-based differences in factors influencing medical lethality. Results show older males have lower lethality risk with family loss (adjusted odds ratio: 0.08) but higher risk with increased intent (some AOR: 11.31, certain AOR: 28.75), intensifying with age. Older females' risk is lower if employed (AOR: 0.28). Suicide method also impacts lethality (agricultural chemicals AOR: 3.71; psychiatric medication AOR: 0.31). Understanding these sex-specific factors aids in targeted preventive strategies for elderly suicide attempts.