Redefining the epidemiology of cardiac amyloidosis. A systematic review and meta‐analysis of screening studies

An algorithm for non‐invasive diagnosis of amyloid transthyretin cardiac amyloidosis (ATTR‐CA) and novel disease‐modifying therapies have prompted an active search of CA. The present study performed a systematic search for screening studies on CA, focusing on the prevalence, sex and age distribution in different clinical settings. The average age of CA patients in the different settings ranged from 74 to 90 years, and the percentage of men was from 50% to 100%. Searching for CA in specific settings allows identifying a relatively high number of cases which may be eligible for treatment if the diagnosis is unequivocal. ATTR‐CA accounts for many cases of CA across the different settings, but AL‐CA is not infrequent. The median age at diagnosis falls in the eighth or ninth decades, and many patients diagnosed with CA are women.