ONCOLOGY

A systematic review of 265 studies reveals synergy trends in antibiotic combinations against Staphylococcus aureus, highlighting glycopeptide-cephalosporin pairs for future clinical focus.

Synergistic Antibiotic Combos Evaluated for Staphylococcus aureus Treatment

This systematic review analyzed 265 in vitro studies examining two-drug combinations against Staphylococcus aureus, including MRSA and MSSA. Time-kill and checkerboard assays were most common. Synergy rates varied widely depending on the drugs and strains tested. Glycopeptide-cephalosporin combinations were most frequently studied. Future research should prioritize combinations with strong biological rationale and clinical potential for treating resistant S. aureus infections.

OPHTHALMOLOGY

Age-stratified anterior chamber depth may improve long-term risk assessment for ICL surgery.

Age-Stratified ACD May Improve ICL Surgery Risk Assessment

A structured narrative review suggests that current anterior chamber depth criteria for Implantable Collamer Lens (ICL) surgery may not adequately account for age-related lens thickening and vault-related crowding. The authors propose age-stratified minimum ACD values of 3.2, 3.1, and 3.0 mm for the third, fourth, and fifth decades, respectively, as risk-stratification factors.

TTMV-HPV DNA testing showed high diagnostic and surveillance accuracy in HPV-positive non-oropharyngeal HNSCC.

TTMV-HPV DNA Testing in Non-Oropharyngeal HNSCC

A retrospective study of HPV-positive non-oropharyngeal HNSCC found that TTMV-HPV DNA testing achieved 80% sensitivity and 100% specificity for diagnosis. During surveillance, sensitivity reached 87% per test and 86% per patient, with positive tests detecting recurrence up to 110 days before clinical or radiographic evidence.

SD-OCT identified diverse outer retinal patterns in cone dysfunction disorders, associated with age and retinal thickness.

SD-OCT Patterns in Cone Dysfunction Disorders

A retrospective study of 42 patients with cone dysfunction disorders identified diverse outer retinal abnormalities on spectral-domain optical coherence tomography (SD-OCT). Outer retinal atrophy was the most common pattern (24.4%), followed by poorly delineated outer retinal bands (22.0%) and ellipsoid zone disruption (19.5%). OCT patterns were associated with age and central retinal thickness but not visual acuity.

High myopia reduced choroidal thickness, while prediabetes was associated with increased SFCT in a Korean population study.

High Myopia and Glucose Metabolism Linked to Choroidal Thickness

A nationwide Korean population-based study of 9,132 participants found that high myopia was strongly associated with reduced subfoveal choroidal thickness (SFCT), while prediabetes was linked to a modest increase. No significant association was found between diabetes and SFCT, and no interaction between myopia and glucose metabolism was observed, suggesting additive rather than synergistic effects.

PULMONOLOGY

Right ventricular IRT may provide a noninvasive marker of pulmonary vascular involvement in patients with COPD.

Echocardiographic IRT for Pulmonary Hypertension in COPD

A retrospective study of 58 patients with stable COPD found that right ventricular isovolumetric relaxation time (IRT) was prolonged in those with pulmonary hypertension. IRT moderately correlated with pulmonary vascular resistance, six-minute walk distance, and dyspnea severity, while conventional right ventricular systolic measures showed no significant associations with pulmonary vascular resistance.

High myopia was linked to thinner choroid, while prediabetes was associated with increased choroidal thickness.

High Myopia and Prediabetes Associated With Choroidal Thickness

A nationwide Korean study of 9,132 participants found that high myopia was strongly associated with thinner subfoveal choroidal thickness, while prediabetes was linked to a modest increase. High myopia reduced SFCT by 107.25 units, whereas diabetes showed no significant association. No interaction between myopia and glucose metabolism was observed.

FineVision HP trifocal IOL provided accurate refraction and favorable distance, intermediate, and near vision at 3 months.

FineVision HP Trifocal IOL Outcomes After Refractive Lens Exchange

A prospective study of 35 patients undergoing bilateral refractive lens exchange with the FineVision HP trifocal IOL found high refractive accuracy and favorable distance, intermediate, and near vision at 3 months. Nearly 94% of eyes achieved a spherical equivalent within ±0.50 D, while 100% of patients achieved binocular distance and near visual acuity of at least 20/20 or better.

qCSF testing revealed reduced uncorrected visual performance in myopic children, supporting early refractive correction.

Quantitative Contrast Sensitivity and Myopia in Children

A study of 57 children found that quantitative contrast sensitivity function (qCSF) improved significantly after refractive correction in those with myopia. The difference between corrected and uncorrected qCSF increased linearly with myopia severity, while results in children without myopia were similar before and after correction, supporting qCSF as a potential screening tool.

Liposomal ozonated oil was well tolerated and showed outcomes comparable to standard prophylaxis after cataract surgery.

Liposomal Ozonated Oil After Cataract Surgery: Pilot Study

A prospective pilot study of 33 patients undergoing bilateral cataract surgery found that liposomal ozonated oil was well tolerated and produced ocular surface outcomes comparable to standard prophylaxis. No postoperative infectious complications occurred. Although some findings suggested potential benefits for foreign body sensation and tear stability, differences were not statistically significant.

DENTISTRY

Root canal treatment showed favorable healing and tooth survival in irradiated head and neck cancer patients.

Root Canal Treatment Outcomes After Radiotherapy for Head and Neck Cancer

A retrospective study of 82 patients with head and neck cancer found favorable healing and survival after non-surgical root canal treatment following radiotherapy. Among teeth assessed at 1–4 years, 82.4% were healed or healing. Estimated tooth survival was 85.8% at 7 years, while preoperative tooth mobility strongly predicted poorer healing and tooth loss.

UROLOGY

PAHG was linked to lower 2-year retreatment rates than other FDA-approved bulking agents for stress urinary incontinence.

PAHG Shows Lower Retreatment Rates in Stress Incontinence

A multicenter study of 623 women found that polyacrylamide hydrogel (PAHG) was associated with significantly lower retreatment rates than other FDA-approved urethral bulking agents. At 2 years, retreatment occurred in 24.4% of PAHG-treated women versus 44.3% with other agents, suggesting greater durability in real-world SUI care.

GYNAECOLOGY - IVF

FIGO and IGCS do not endorse routine topical treatments for HR-HPV or LSIL due to insufficient clinical evidence.

FIGO, IGCS Advise Against Topical HR-HPV Treatments

FIGO and IGCS do not recommend routine use of topical therapies for high-risk HPV infection or low-grade cervical lesions, citing insufficient evidence of clinically meaningful benefit. Existing studies rely largely on surrogate outcomes, with small samples, short follow-up, heterogeneity and methodological concerns. Evidence-based surveillance remains the standard of care.

Submerged healing improved esthetics and satisfaction, while overall 2-year peri-implantitis treatment success was comparable.

Submerged vs Non-Submerged Healing in Peri-Implantitis

A retrospective study of 33 patients and 53 implants found comparable 2-year treatment success between submerged and non-submerged healing after reconstructive peri-implantitis surgery. Submerged healing showed better esthetic outcomes and patient satisfaction, while prior periodontitis and greater baseline probing depth predicted less favorable outcomes.

NEUROLOGY

EV-associated CFL1 showed strong diagnostic accuracy and distinguished Parkinson’s disease from atypical parkinsonism.

EV-CFL1 Emerges as Potential Parkinson’s Biomarker

A 2026 Annals of Neurology study identified extracellular vesicle-associated cofilin 1 (EV-CFL1) as a potential blood-based biomarker for Parkinson’s disease. EV-CFL1 was significantly elevated in PD and showed strong diagnostic accuracy (AUC 0.87), while distinguishing PD from progressive supranuclear palsy (AUC 0.914).

PSYCHIATRY

Anxiety may help identify distinct callous-unemotional trait variants and complex clinical needs in youth with conduct disorder.

Anxiety Identifies CU Trait Variants in Youth With Conduct Disorder

A study of 288 male adolescents with DSM-5 conduct disorder found that anxiety may help distinguish primary and secondary callous-unemotional trait variants. Youth with high anxiety showed greater psychopathic traits, affective empathy, depression, emotional maltreatment and sexual abuse, suggesting more complex clinical and environmental needs.

Synergistic Antibiotic Co...

Synergistic Antibiotic Combinations Against Staphylococcus aureus Reviewed