The metabolic response of human trophoblasts derived from term placentas to metformin

A new study delves into the effects of metformin use during pregnancy, a common treatment for gestational diabetes. Researchers found that metformin impacts placental metabolism by reducing oxidative phosphorylation and increasing glycolysis, potentially leading to decreased birthweight. The study also highlights the accumulation of lipids, including long-chain polyunsaturated fatty acids, in metformin-treated placental cells. These findings raise concerns about the risks and benefits of metformin use during pregnancy, especially when alternative therapies are an option.