The Triglycerides and Glucose Index is not superior to HOMA‐IR in predicting testosterone deficiency among adult males

Testosterone decline and deficiency in males have aroused increased attention in male health management, which might have a close relationship with insulin resistance (IR). A novel IR indicator, the triglyceride‐glucose (TyG) index, was used to investigate the link between the TyG index and serum testosterone in US adult males. Participants with a higher TyG index showed a lower total testosterone level and a higher testosterone deficiency. Males in TyG index tertile 3 had a 113% higher risk of testosterone deficiency than those in tertile 1. Subgroup analysis stratified by diabetes condition indicated that the TyG index might be a good predictor of testosterone deficiency in people with or without diabetes. However, the predictability of the TyG index for testosterone deficiency was not better than that of HOMA‐IR.