Trajectories of renal biomarkers and new onset heart failure in the general population: Findings from the PREVEND study

The study aimed to examine the association between repeated measures of renal function and the development of heart failure (HF). The researchers analyzed data from the Prevention of Renal and Vascular End‐stage Diseases (PREVEND) study, including 6,881 participants, and tracked the trajectories of urinary albumin excretion (UAE) and serum creatinine over an 11-year period. Most participants had stable low UAE or serum creatinine levels. However, those with persistently higher UAE or serum creatinine were older, more likely to be men, and had comorbidities like diabetes and previous myocardial infarction. Participants with persistently high UAE had a higher risk of new-onset HF and all-cause mortality, while stable serum creatinine levels showed a linear association with new-onset HF but no association with all-cause mortality. In conclusion, patients with consistently worse renal function were at a higher risk of HF and mortality.