Trajectories of renal biomarkers and new‐onset heart failure in the general population: findings from the PREVEND study

In the PREVEND study, researchers analyzed data from European adults to understand the relationship between renal biomarkers and the development of heart failure (HF). They found distinct patterns of urinary albumin excretion (UAE) and serum creatinine levels over time. Participants with consistently high UAE or serum creatinine levels were older, more likely to be male, and had comorbidities like diabetes and dyslipidemia. Persistently high UAE was associated with an increased risk of new-onset HF and all-cause mortality. Stable serum creatinine levels showed a linear association with new-onset HF but no association with all-cause mortality.