Trim14 promotes osteoclastogenesis and noncanonical NF‐κB activation by targeting p100/p52 in chronic periodontitis

TRIM14 is identified as a novelmediator of the noncanonical NF‐κB signaling pathway in osteoclastogenesis and chronic periodontitis in vitro and in vivo. Periodontitis disease infection initiates host immune response, and alveolar bone damage is a hallmark of periodontitis. Bone damage occurs due to changes in osteoclast activity in response to local inflammation. Nuclear factor κB (NF‐κB) signaling is essential for inflammatory responses and plays a pivotal role in osteoclast formation and activation...